Cyclic amino compounds for use in the treatment of cardiac disorders
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United States of America Patent
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Mar 7, 2017
Grant Date -
May 21, 2015
app pub date -
Nov 20, 2014
filing date -
Nov 26, 2013
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Abstract
The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP18δ) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl) amine structure.
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