Implantable nerve conduit having a polymer fiber spiral guidance channel

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 9585666
APP PUB NO 20140379009A1
SERIAL NO

14313384

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Abstract

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A nerve guidance conduit includes a spiral structured porous sheet decorated with channels on its surface and electrospun nanofibers in a parallel alignment with the channels and an outer tubular structure including randomly-oriented nanofibers. Such a structure provides augmented surface areas for providing directional guidance and augmented surfaces for enhancing and peripheral nerve regeneration. The structure also has the mechanical and nutrient transport requirements required over long regeneration periods. To prepare a nerve guidance conduit, porous polymer sheet is prepared by a solvent casting method while using a template of thin rods to form parallel channels on a surface of the sheet. Aligned nanofibers are deposited on the sheet parallel to the channels. The polymer sheet is then wound to form a spiral structure. A dense layer of randomly-oriented nanofibers may be deposited on the outside of the spiral.

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Patent Owner(s)

Patent OwnerAddress
THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGYCASTLE POINT ON HUDSON HOBOKEN NJ 07030

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chang, Wei New York, US 173 2897
Yu, Xiaojun Fishers, US 74 1789

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