Uses of modified human tumor necrosis factor receptor-1 polypeptide

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United States of America Patent

PATENT NO 9580490
APP PUB NO 20150119338A1
SERIAL NO

14404001

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Abstract

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The present invention relates to new uses of modified human tumor necrosis factor receptor-1 (TNFRI) polypeptide, and more particularly, to uses thereof for prevention and treatment of dry eye syndrome. The modified TNFRI or modified TNFRI fragment of the present invention has excellent TNFα neutralizing activity, and inhibits TNFα activity on the ocular surface of the patient to suppress inflammation induction effects related to dry eye. Therefore, the modified TNFRI or modified TNFRI fragment of the present invention exhibits remarkable effects in the prevention and treatment of dry eye syndrome, and thus can be very useful in the prevention and treatment of dry eye syndrome.

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Patent Owner(s)

Patent OwnerAddress
DAEWOONG PHARMACEUTICAL CO LTD35-14 JEYAKGONGDAN 4-GIL HYANGNAM-EUP HWASEONG-SI GYEONGGI-DO 18623

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ahn, Hyea Kyung Gyeonggi-do, KR 13 6
Jeong, Jae Kap Gyeonggi-do, KR 19 18
Kim, Eun Sun Seoul, KR 187 3293
Kim, Sung Wuk Gyeonggi-do, KR 51 282
Lee, Hung Keun Seoul, KR 1 0
Park, Seung Kook Seoul, KR 24 20
Song, Yeon Jung Gyeonggi-do, KR 15 15

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