Vaccines comprising heat-sensitive transgenes
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United States of America Patent
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Feb 28, 2017
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Mar 12, 2013
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Oct 7, 2009
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Abstract
The present disclosure provides temperature sensitive essential nucleic acid molecules from a psychrophilic bacterium, proteins encoded by the nucleic acid molecules, as well as recombinant cells into which have been introduced such nucleic acid molecules. The disclosed recombinant cells containing one or more essential nucleic acid molecules from a psychrophilic bacterium are thereby made temperature sensitive, and can be administered to a mammal to induce an immune response in the mammal.
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