Compositions for binding to amyloid proteins
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United States of America Patent
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Feb 28, 2017
Grant Date -
Dec 4, 2014
app pub date -
Oct 10, 2012
filing date -
Oct 10, 2011
priority date (Note) -
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Abstract
Compositions useful for the prevention and/or treatment of Alzheimer's disease are disclosed. The composition comprises carrier particles each linked to a plurality of peptide constructs comprising a peptide binding sequence capable of binding to an amyloid protein and a transit amino acid sequence linked to said binding sequence. The binding sequence may be retroinverted D-peptide mimetic of an L-peptide binding sequence and the transit sequence may be a D-peptide mimetic of an L-peptide transit sequence (e.g. TAT) The preferred peptide construct comprises the sequence rGffvlkGrrrrqrrkkrGy. The preferred carrier particles are liposomes.
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