Delivery of therapeutic agents by a collagen binding protein

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United States of America Patent

PATENT NO 9579273
SERIAL NO

14365226

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Abstract

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Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

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Patent Owner(s)

Patent OwnerAddress
MONTEFIORE MEDICAL CENTER111 EAST 210 STREET BRONX NY 10467

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gensure, Robert C New York, US 12 115
Katikaneni, Ranjitha New York, US 5 34
Koide, Takaki Tokyo, JP 8 36
Matsushita, Osamu Kanagawa, JP 26 241
Nishi, Nozomu Kagawa, JP 16 103
Philominathan, Sagaya Theresa Leena Cheshire, US 5 34
Ponnapakkam, Tulasi New York, US 10 75
Sakon, Joshua Fayetteville, US 19 110

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