MicroRNA compounds and methods for modulating miR-122
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United States of America Patent
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Feb 21, 2017
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Feb 29, 2016
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May 1, 2013
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Abstract
Described herein are compositions and methods for the inhibition of miR-122 activity. The compositions have certain nucleoside modifications that yield potent inhibitors of miR-122 activity. The compounds may comprise conjugates to facilitate delivery to the liver. The compositions may be administered to subjects infected with hepatitis C virus, as a treatment for hepatitis C virus and related conditions.
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