Stable heterodimeric antibody design with mutations in the Fc domain
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United States of America Patent
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Feb 21, 2017
Grant Date -
Aug 1, 2013
app pub date -
Nov 2, 2012
filing date -
Nov 4, 2011
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Abstract
The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. CH2 and CH3) to accomplish selectivity between the various Fc receptors involved in modulating effector function, beyond those achievable with a natural homodimeric (symmetric) Fc molecule, and increased stability and purity of the resulting variant Fc heterodimers. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics.
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