Catalytic method for dibenzocycloheptane synthesis and allocolchicinoid synthesis
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United States of America Patent
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Feb 21, 2017
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Dec 3, 2015
app pub date -
Jun 2, 2015
filing date -
Jun 3, 2014
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Abstract
In a non-limiting embodiment, there is provided a compound of formula (I), which may permit for a method or use in treating or preventing a cancer, such as pancreatic cancer or leukemia. In one embodiment, there is also provide a method of preparing a compound of formula (Ia), the method including conducting a cyclization reaction of a compound of formula (III) to obtain a compound of formula (IV), wherein conducting the cyclization reaction comprises conducting a Michael reaction in the presence of a Lewis acid.
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