Utility of B-RAF DNA mutation in diagnosis and treatment of cancer
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United States of America Patent
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Feb 14, 2017
Grant Date -
Nov 22, 2012
app pub date -
May 11, 2012
filing date -
Feb 26, 2007
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Abstract
The present invention discloses a method of detecting a wild-type or mutant B-RAF gene in a body fluid sample from a subject. Also disclosed are methods of using B-RAF as a biomarker for detecting cancer, predicting the outcome of cancer, and monitoring the treatment of cancer or the status of cancer. Furthermore, the invention discloses methods and compositions for detecting a mutant gene with a peptide nucleic acid clamp capable of hybridizing to a wild-type gene and a locked nucleic acid probe capable of hybridizing to a mutant of the gene.
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