Method for predicting the response to treatment with an HER2-blocking agent
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United States of America Patent
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Feb 14, 2017
Grant Date -
Dec 25, 2014
app pub date -
Jun 7, 2012
filing date -
Jun 10, 2011
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Abstract
The invention relates in particular to an in vitro or ex vivo method for predicting the response of a patient to treatment with at least one HER2-blocking agent, said method including the steps of: i) identifying the nucleotide at the rs3746083 polymorphic site, for at least one allele, in particular the two alleles of the gene coding the tristetraprolin protein, in a biological sample from said patient; and/or ii) determining the concentration of the tristetraprolin protein in a biological sample from said patient, wherein said patient is suffering from HER2-positive cancer.
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