Dasatinib and nonlinear configuration polyethylene glycol conjugate
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United States of America Patent
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Feb 14, 2017
Grant Date -
Apr 7, 2016
app pub date -
Dec 16, 2015
filing date -
Jun 18, 2013
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Abstract
A dasatinib and nonlinear configuration polyethylene glycol conjugate represented by formula I, wherein core is the core structure of a nonlinear configuration of polyethylene glycol, selected from a residue of pentaerythritol, methylglucoside, sucrose, diethylene glycol, propanediol, glycerol or polyglycerol removaed the hydrogen atom from the hydroxyl group; P is a polyethylene glycol residue with a number-average molecular weight of 300-60000 Da; X is selected from single bond, —CH2CO—, —CH2CH2OCO— or CH2CH2NHCO—; and i is selected from 3, 4, 6 or 8.
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