Systems and methods of using chemically bound antibiotics activated by infections
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United States of America Patent
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Feb 14, 2017
Grant Date -
Sep 18, 2014
app pub date -
Mar 14, 2014
filing date -
Mar 14, 2013
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Abstract
Methods, devices and systems are disclosed for chemically bonding antibiotics to selected substrate materials which are not dissolved in normal physiological processes so that high local concentrations can be achieved during the inflammatory response. The antibiotics will remain permanently bonded to the substrate material until an infection occurs which releases the antibiotic in high concentrations to help control the infection. The high local concentrations may be much higher than systemic toxic levels, and can never reach toxic levels because the local dose is much less than needed to reach systemic toxicity if completely dissolved.
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