Methods for reducing intraocular pressure by administering a soluble hyaluronidase glycoprotein (sHASEGP)
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United States of America Patent
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Feb 7, 2017
Grant Date -
Jul 17, 2014
app pub date -
Feb 26, 2014
filing date -
Mar 5, 2003
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Abstract
Provided are methods for reducing intraocular pressure in the eye of a subject by administering neutral active soluble active hyaluronidase glycoproteins (sHASEGPs) and modified forms thereof to the eye. The sHASEGPs are soluble forms of human PH20 hyaluronidase. Also provided are the sHASEGPs, methods of manufacture, and uses thereof. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described. The sHASEGPs include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain.
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