Methods for identifying broadly neutralizing antibodies utilizing recombinant HIV-1 envelope glycoproteins comprising stabilizing mutations
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United States of America Patent
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Feb 7, 2017
Grant Date -
Feb 6, 2014
app pub date -
Jun 27, 2013
filing date -
Jun 27, 2012
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Abstract
The present application relates to novel HIV-1 envelope glycoproteins which may be utilized as an HIV-1 vaccine immunogens, antigens for crystallization and for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
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