Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof
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United States of America Patent
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Feb 7, 2017
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app pub date -
Jan 30, 2015
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Jan 31, 2014
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Abstract
The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator (uPA), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator in a variety of therapeutic, diagnostic and prophylactic indications.
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