(+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
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United States of America Patent
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Feb 7, 2017
Grant Date -
Jun 9, 2011
app pub date -
Dec 22, 2010
filing date -
Jul 16, 2009
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Abstract
The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.
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