Solubility optimization of immunobinders
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United States of America Patent
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Jan 31, 2017
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Nov 3, 2011
app pub date -
Jun 25, 2009
filing date -
Jun 25, 2008
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Abstract
The invention provides methods of using sequence based analysis and rational strategies to improve the solubility of immunobinders, and in particular of single chain antibodies (scFvs). The invention provides methods of engineering immunobinders, and in particular scFvs, by performing one or more substitutions with hydrophilic residues identified by analysis of a database of selected, stable scFv sequences. The invention also provides immunobinders with optimized solubility prepared according to the engineering methods of the invention.
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