Modification of peptides using a bis(thioether)arylbridge approach
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United States of America Patent
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Jan 31, 2017
Grant Date -
May 14, 2015
app pub date -
May 17, 2013
filing date -
May 18, 2012
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Abstract
This invention provides novel methods of stabilizing peptides and peptides so stabilized. In certain embodiments the methods involve providing a peptide containing at least two S bearing residues within the peptide; and reacting the peptide with a di-halogen-aryl-compounds to form a bis(thioether)-aryl-bridge between said two residues.
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