Process for the preparation of drospirenone
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United States of America Patent
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Jan 31, 2017
Grant Date -
Feb 25, 2016
app pub date -
Apr 12, 2013
filing date -
Apr 12, 2013
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Abstract
A process is disclosed wherein, using either 17a-(3-hydroxypropyl)-6p,7p;15p,16p-dimethylene-5p-androstane-3p,5,17p-triol (II) or 3β,5^ïI^κ^-6β,7β;15β,16β-dimethylene-5β,17α-pregnane-21,17-carbolactone (III) as starting material, through a single-step reaction it is obtained drospirenone (I), a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for preparing pharmaceutical compositions with contraceptive action.
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