Approach for synthesis of catechins

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United States of America Patent

PATENT NO 9556140
SERIAL NO

14763018

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Abstract

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A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or −) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.

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Patent Owner(s)

Patent OwnerAddress
EPIRIUM BIO INCC/O LATHAM & WATKINS LLP 12670 HIGH BLUFF DRIVE SAN DIEGO CA 92130

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dugar, Sundeep IMT Manesar, IN 112 1991
Mahajan, Dinesh IMT Manesar, IN 18 47
Patil, Ishwar Rakesh IMT Manesar, IN 3 27
Rai, Kumar Santosh IMT Manesar, IN 2 4
Tripathi, Vinayak IMT Manesar, IN 11 97

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