Combination uses of dichloroacetate and oxamate, and their prodrugs, for cancer treatment

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United States of America Patent

PATENT NO 9556113
APP PUB NO 20150315131A1
SERIAL NO

14699946

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Abstract

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The invention novel compounds, pharmaceutical compositions and methods useful for preventing or treating cancer in animals and humans. Also, the invention provides novel prodrugs useful for reducing tumor size, and inhibiting the growth of cancers, inhibiting tumor cell growth and tumor cell proliferation, and promoting apoptosis of tumor cells. When used in combination with chemoradiation therapy, the novel compounds, compositions and prodrugs provided herein can improve the effectiveness of chemoradiation therapy. The novel compounds, compositions and prodrugs of the invention inhibit PDK and LDH in unique and effective ways.

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Patent Owner(s)

Patent OwnerAddress
SANFORD RESEARCH2301 EAST 60TH STREET NORTH SIOUX FALLS SD 57104

International Classification(s)

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  • 2015 Application Filing Year
  • A61K Class
  • 16157 Applications Filed
  • 11882 Patents Issued To-Date
  • 73.55 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201520162017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dwivedi, Chandrahar Brookings, US 1 2
Guan, Xiangming Brookings, US 3 2
Lee, John H Sioux Falls, US 59 175
Li, Yinghong Beijing, CN 10 22
Miskimins, Wilson Keith Alcester, US 1 2
Yang, Yang Brookings, US 1214 8701

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Patent Citation Ranking

  • 2 Citation Count
  • A61K Class
  • 45.09 % this patent is cited more than
  • 8 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges763281956782001332911183139501 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +050010001500200025003000350040004500500055006000650070007500800085009000

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