Combination uses of dichloroacetate and oxamate, and their prodrugs, for cancer treatment
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
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Jan 31, 2017
Grant Date -
Nov 5, 2015
app pub date -
Apr 29, 2015
filing date -
Apr 29, 2014
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The invention novel compounds, pharmaceutical compositions and methods useful for preventing or treating cancer in animals and humans. Also, the invention provides novel prodrugs useful for reducing tumor size, and inhibiting the growth of cancers, inhibiting tumor cell growth and tumor cell proliferation, and promoting apoptosis of tumor cells. When used in combination with chemoradiation therapy, the novel compounds, compositions and prodrugs provided herein can improve the effectiveness of chemoradiation therapy. The novel compounds, compositions and prodrugs of the invention inhibit PDK and LDH in unique and effective ways.
First Claim
all claims..Other Claims data not available
Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
SANFORD RESEARCH | 2301 EAST 60TH STREET NORTH SIOUX FALLS SD 57104 |
International Classification(s)

- 2015 Application Filing Year
- A61K Class
- 16157 Applications Filed
- 11882 Patents Issued To-Date
- 73.55 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Dwivedi, Chandrahar | Brookings, US | 1 | 2 |
# of filed Patents : 1 Total Citations : 2 | |||
Guan, Xiangming | Brookings, US | 3 | 2 |
# of filed Patents : 3 Total Citations : 2 | |||
Lee, John H | Sioux Falls, US | 59 | 175 |
# of filed Patents : 59 Total Citations : 175 | |||
Li, Yinghong | Beijing, CN | 10 | 22 |
# of filed Patents : 10 Total Citations : 22 | |||
Miskimins, Wilson Keith | Alcester, US | 1 | 2 |
# of filed Patents : 1 Total Citations : 2 | |||
Yang, Yang | Brookings, US | 1214 | 8701 |
# of filed Patents : 1214 Total Citations : 8701 |
Cited Art Landscape
- No Cited Art to Display

Patent Citation Ranking
- 2 Citation Count
- A61K Class
- 45.09 % this patent is cited more than
- 8 Age
Forward Cite Landscape
- No Forward Cites to Display

Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
---|---|---|---|---|
11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jul 31, 2028 |
Fee | Large entity fee | small entity fee | micro entity fee |
---|---|---|---|
Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
Full Text

Legal Events
Date | Code | Event | Description |
---|---|---|---|
Mar 10, 2025 | LAPS | LAPSE FOR FAILURE TO PAY MAINTENANCE FEES | free format text: PATENT EXPIRED FOR FAILURE TO PAY MAINTENANCE FEES (ORIGINAL EVENT CODE: EXP.); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY |
Mar 10, 2025 | STCH | INFORMATION ON STATUS: PATENT DISCONTINUATION | free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |
Jan 31, 2025 | FP | LAPSED DUE TO FAILURE TO PAY MAINTENANCE FEE | Effective Date: Jan 31, 2025 |
Sep 23, 2024 | FEPP | FEE PAYMENT PROCEDURE | free format text: MAINTENANCE FEE REMINDER MAILED (ORIGINAL EVENT CODE: REM.); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY |
Jul 30, 2020 | MAFP | MAINTENANCE FEE PAYMENT | free format text: PAYMENT OF MAINTENANCE FEE, 4TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: M2551); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY year of fee payment: 4 |
Jan 31, 2017 | I | Issuance | |
Jan 11, 2017 | STCF | INFORMATION ON STATUS: PATENT GRANT | free format text: PATENTED CASE |
Nov 05, 2015 | P | Published | |
Jul 09, 2015 | AS | ASSIGNMENT | free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:LEE, JOHN H.;MISKIMINS, WILSON KEITH;SIGNING DATES FROM 20150706 TO 20150707;REEL/FRAME:036045/0228 Owner name: SANFORD RESEARCH, SOUTH DAKOTA |
Jun 25, 2015 | AS | ASSIGNMENT | free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GUAN, XIANGMING;DWIVEDI, CHANDRAHAR;LI, YINGHONG;AND OTHERS;SIGNING DATES FROM 20150609 TO 20150618;REEL/FRAME:035965/0808 Owner name: THE SOUTH DAKOTA BOARD OF REGENTS, SOUTH DAKOTA |
Apr 29, 2015 | F | Filing | |
Dec 04, 2013 | PD | Priority Date |

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