Combination uses of dichloroacetate and oxamate, and their prodrugs, for cancer treatment
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United States of America Patent
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Jan 31, 2017
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Nov 5, 2015
app pub date -
Apr 29, 2015
filing date -
Apr 29, 2014
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Abstract
The invention novel compounds, pharmaceutical compositions and methods useful for preventing or treating cancer in animals and humans. Also, the invention provides novel prodrugs useful for reducing tumor size, and inhibiting the growth of cancers, inhibiting tumor cell growth and tumor cell proliferation, and promoting apoptosis of tumor cells. When used in combination with chemoradiation therapy, the novel compounds, compositions and prodrugs provided herein can improve the effectiveness of chemoradiation therapy. The novel compounds, compositions and prodrugs of the invention inhibit PDK and LDH in unique and effective ways.
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