Modulation of fibroblast activity
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United States of America Patent
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Jan 31, 2017
Grant Date -
Aug 18, 2011
app pub date -
Mar 27, 2009
filing date -
Mar 27, 2008
priority date (Note) -
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Abstract
The invention includes a method for combating scarring in a subject, the method comprising administering to the subject an agent which positively modulates β2-adrenergic receptor; a method for simultaneously decreasing the amount of TGFβ1 and increasing the amount of TGFβ3 produced by a fibroblast, the method comprising contacting the fibroblast with an agent which positively modulates β2-adrenergic receptor; a method for reducing fibroblast differentiation, the method comprising contacting the fibroblast with an agent which positively modulates β2-adrenergic receptor; and a method of reducing the deposition of collagen in a subject, the method comprising administering to the subject an agent which positively modulates β2-adrenergic receptor.
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