Compositions and methods for modulating myeloid derived suppressor cells
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United States of America Patent
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Jan 24, 2017
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Nov 13, 2014
app pub date -
Dec 3, 2012
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Dec 2, 2011
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Abstract
Provided are methods and compositions for modulating the differentiation of a myeloid derived suppressor cell (MDSC). In particular, described herein are miR-142 polynucleotides and miR-223 polynucleotides that can be used to modulate differentiation of MDSCs. Increased differentiation of a MDSC population, or cells within an MDSC population, can be achieved by increasing the miR-142 and/or miR-223 polynucleotides in a MDSC.
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