Methods for compact aggregation of dermal cells
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United States of America Patent
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Jan 24, 2017
Grant Date -
Mar 10, 2016
app pub date -
Aug 7, 2015
filing date -
Feb 28, 2006
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Abstract
The invention provides for a method for aggregating dermal papilla cells or dermal sheath cells or a combination thereof, the method comprising: growing dermal papilla cells or dermal sheath cells or a combination thereof in suspension culture; and contacting the culture with an effective amount of an enzyme, wherein a substrate of the enzyme is an extracellular matrix molecule in the suspension culture, so as to aggregate dermal papilla cells or dermal sheath cells. The culture may be a hanging drop culture and the enzyme may be a hyaluronidase.
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