Humanized anti-HMGB1 antibody or antigen-binding fragment thereof

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United States of America Patent

PATENT NO 9550825
APP PUB NO 20150361164A1
SERIAL NO

14761152

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Abstract

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The present invention provides a humanized anti-HMGB1 antibody which specifically binds to a sequence consisting of the C-terminal 8 amino acid residues (EEEDDDDE) of HMGB1 protein and is effective for treatment or prevention of various inflammatory diseases related to this protein, as well as an antigen-binding fragment thereof. The present invention also provides a pharmaceutical composition comprising such an antibody or antigen-binding fragment thereof.

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Patent Owner(s)

Patent OwnerAddress
NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY1-1 TSUSHIMA-NAKA 1-CHOME OKAYAMA-SHI OKAYAMA 770-8530

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nishibori, Masahiro Okayama, JP 18 69
Takada, Kenzo Hokkaido, JP 9 34
Torashima, Takashi Hokkaido, JP 4 23

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