Cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use

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United States of America Patent

PATENT NO 9550762
APP PUB NO 20160046618A1
SERIAL NO

14819256

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Abstract

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The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I:

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Patent Owner(s)

Patent OwnerAddress
AMGEN INCONE AMGEN CENTER DRIVE THOUSAND OAKS CA 91320-1799

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Allen, Jennifer R Newbury Park, US 57 505
Amegadzie, Albert Moorpark, US 29 418
Bourbeau, Matthew P Woodland Hills, US 22 144
Brown, James A Moorpark, US 17 214
Chen, Jian J Camarillo, US 74 1665
Cheng, Yuan Newbury Park, US 119 2620
Frohn, Michael J Thousand Oaks, US 46 387
Guzman-Perez, Angel Belmont, US 41 230
Harrington, Paul E Camarillo, US 23 202
Liu, Longbin Thousand Oaks, US 74 1475
Liu, Qingyian Camarillo, US 66 591
Low, Jonathan D Reseda, US 31 393
Ma, Vu Van Oak Park, US 33 488
Manning, James Pleasant Hill, US 16 86
Minatti, Ana Elena Santa Monica, US 41 467
Nguyen, Thomas T Newbury Park, US 39 716
Nishimura, Nobuko West Hills, US 58 912
Norman, Mark H Thousand Oaks, US 67 1528
Pettus, Liping H Thousand Oaks, US 46 545
Pickrell, Alexander J Westlake Village, US 38 337
Qian, Wenyuan Thousand Oaks, US 58 271
Rumfelt, Shannon Camarillo, US 24 366
Rzasa, Robert M Thousand Oaks, US 45 717
Siegmund, Aaron C Ventura, US 32 809
Stec, Markian M Thousand Oaks, US 11 60
White, Ryan D Somerville, US 20 70
Xue, Qiufen Thousand Oaks, US 28 378

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