Method for determining fetal chromosomal abnormality
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United States of America Patent
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Jan 17, 2017
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Apr 10, 2014
app pub date -
Jun 29, 2011
filing date -
Jun 29, 2011
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Abstract
The current invention is directed to methods for noninvasive detection of fetal genetic abnormalities by large-scale sequencing of nucleotides from maternal biological sample. Further provided are methods to remove GC bias from the sequencing results according to the difference in GC content of a chromosome. The current invention not only makes the detection much more accurate but also represents a comprehensive method for fetal aneuploidy detection including sex chromosome disorders such as XO, XXX, XXY, and XYY, etc.
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