Methods of increasing efficiency of vector penetration of target tissue
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United States of America Patent
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Jan 17, 2017
Grant Date -
Jul 25, 2013
app pub date -
Mar 22, 2011
filing date -
Mar 22, 2010
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Abstract
Methods for increasing the efficiency of target tissue penetration of an adeno-associated virus (AAV) vector in a patient are provided. In some aspects, the methods involve inhibiting the interaction of the serum protein galectin 3 binding protein (G3BP) with AAV vector. Further provided are methods for reducing tissue distribution of a virus or for neutralizing a virus harbored by an organ destined for transplant, or newly transplanted, by administering a composition comprising G3BP.
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