Method for increasing the efficiency of double-strand-break induced mutagenesis
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United States of America Patent
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Jan 10, 2017
Grant Date -
Aug 21, 2014
app pub date -
Jul 3, 2012
filing date -
Jul 8, 2011
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Abstract
The present invention relates to a method for increasing double-strand-break induced mutagenesis at a genomic locus of interest in a cell, thereby giving new tools for genome engineering, including therapeutic applications and cell line engineering. More specifically, the present invention concerns the combined use of TALEN or meganucleases with TREX2, especially under the form of single-chain proteins.
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