Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof
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United States of America Patent
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Jan 10, 2017
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app pub date -
Oct 30, 2014
filing date -
Oct 30, 2013
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Abstract
The invention relates generally to variant activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically binds to epidermal growth factor receptor (EGFR), and to methods of making and using these variant anti-EGFR activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
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