Use of antibodies for detection of IL-10

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United States of America Patent

PATENT NO 9540436
APP PUB NO 20150218270A1
SERIAL NO

14591133

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Abstract

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Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof: (i) binds to the same region of IL-10 as the IL-10 receptor α (IL-I10Ra) and is not capable of binding IL-10 when the IL-10 is bound to the IL-10 receptor; and (ii) binds to IL-10 in homodimeric form by binding a discontinuous epitope comprising residues of both monomers. Further provided are related products and methods involving the use of the antibody or fragment thereof.

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Patent Owner(s)

Patent OwnerAddress
BIOTEST AG63303 DREIEICH

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bruecher, Christoph Eschborn, DE 18 212
Czeloth, Niklas Dreieich, DE 7 49
Daelken, Benjamin Frankfurt am Main, DE 24 242
Engling, André Bad Homburg, DE 5 27
Osterroth, Frank Dietzenbach, DE 18 201
Röttgen, Peter Ladenburg, DE 6 19
Uherek, Christoph Seligenstadt, DE 26 324
Zuber, Chantal Frankfurt am Main, DE 9 53

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