6-arylamino pyridone carboxamide as MEK inhibitors
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United States of America Patent
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Jan 10, 2017
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Mar 20, 2014
app pub date -
Nov 1, 2011
filing date -
Nov 2, 2010
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Abstract
The invention provides novel substituted 6-arylamino pyridone carboxamides represented by Formula I, or a pharmaceutically acceptable salt, solvate, poly-morph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans.
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