Isomannide derivatives as inhibitors of soluble epoxide hydrolase
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United States of America Patent
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Jan 10, 2017
Grant Date -
Nov 26, 2015
app pub date -
Jan 16, 2014
filing date -
Jan 17, 2013
priority date (Note) -
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Abstract
The present invention relates to compounds of the formula (I), wherein R1, R11, R12 and X have the meanings indicated in the claims. The compounds of formula I are valuable pharmacologically active compounds. They are highly potent and selective soluble epoxide hydrolase inhibitors and are suitable, for example, for the therapy and prophylaxis of renal failure, diabetic nephropathy, type 2 diabetes mellitus, inflammation or could show beneficial effects in pain, dyslipidemia and atherosclerosis. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
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