Nasal vaccine against the development of atherosclerosis disease and fatty liver
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United States of America Patent
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Jan 10, 2017
Grant Date -
Nov 19, 2015
app pub date -
Jun 26, 2013
filing date -
Jun 28, 2012
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Abstract
The present invention provides a novel vaccine compound of micellar nanoparticles to be administered intranasally to treat and/or prevent the disease called atherosclerosis, which results from an abnormal metabolism of circulating lipids. The novelty of the vaccine compound of the present invention is the use of Archaebacterian lipids, lysophosphatidylcholine, and phosphatidylcholine, which give nanoparticles stability and facilitates antigen presentation in its appropriate secondary peptidic conformation. A novel process for the preparation of vaccine compounds which allows obtaining homogeneous nanoparticles with high stability is also presented in this invention.
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