Mutant ROS expression in human cancer

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United States of America Patent

PATENT NO 9539254
APP PUB NO 20150119403A1
SERIAL NO

14483681

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Abstract

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The invention provides the identification of the presence of mutant ROS protein in human cancer. In some embodiments, the mutant ROS are FIG-ROS fusion proteins comprising part of the FIG protein fused to the kinase domain of the ROS kinase. In some embodiments, the mutant ROS is the overexpression of wild-type ROS in cancerous tissues (or tissues suspected of being cancerous) where, in normal tissue of that same tissue type, ROS is not expressed or is expressed at lower levels. The mutant ROS proteins of the invention are anticipated to drive the proliferation and survival of a subgroup of human cancers, particularly in cancers of the liver (including bile duct), pancreas, kidney, and testes. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ROS polypeptides (e.g., a FIG-ROS(S) fusion polypeptide), probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The identification of the mutant ROS polypeptides enables new methods for determining the presence of these mutant ROS polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention.

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Patent Owner(s)

Patent OwnerAddress
CELL SIGNALING TECHNOLOGY INC3 TRASK LANE DANVERS MASSACHUSETTS 01923 01923

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Crosby, Katherine Eleanor Middelton, US 17 13
Gu, Ting-Lei Woburn, US 51 134
Haack, Herbert South Hamilton, US 31 73
Rimkunas, Victoria McGuinness Somerville, US 12 13
Tucker, Meghan Ann Salem, US 7 9

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