type IV pili

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United States of America Patent

PATENT NO 9533033
APP PUB NO 20160175424A1
SERIAL NO

15062897

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable H. influenzae (NTHi) and from H. influenzae strains a, b, c, e and f. The invention provides isolated H. influenzae pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to H. influenzae and methods of treating and preventing H. influenzae related pathological conditions.

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Patent Owner(s)

Patent OwnerAddress
NATIONWIDE CHILDREN'S HOSPITAL INC700 CHILDREN'S DRIVE COLUMBUS OH 43205

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bakaletz, Lauren O Hilliard, US 72 970
Munson,, Jr Robert S Columbus, US 25 406

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