Polymutant tau protein variants and their use for recapitulating human tauopathies
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United States of America Patent
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Dec 27, 2016
Grant Date -
Jun 12, 2014
app pub date -
Apr 28, 2011
filing date -
Apr 28, 2011
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Abstract
Disclosed herein are methods for identifying an agent for treating or preventing neurogenerative disease and to methods for recapitulating tauopathies using a tau protein that includes at least four different mutations that cause the condition frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and to nucleic acids encoding the tau protein.
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