Salt and polymorph of pyrazolopyrimidinone compound, and pharmaceutical composition containing the same, preparation method and use thereof

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United States of America Patent

PATENT NO 9527849
APP PUB NO 20140309241A1
SERIAL NO

14238790

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Abstract

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The present invention relates to new salts of pyrazolopyrimidinone represented by formula (I), and pharmaceutically acceptable polymorph, solvate, hydrate, dehydrate, co-crystallization, anhydrous, or amorphous form thereof, the pharmaceutical compositions, and a pharmaceutical unit dosage form containing the same, wherein x represents organic or inorganic acids, preferable maleic acid, succinic acid, methanesulfonic acid, hydrochloric acid, etc. The invention further relates to co-crystals or complexes of compounds of pyrazolopyrimidinone and pharmaceutical compositions containing the same. The present invention also relates to a process for the preparation, use thereof and pharmaceutical preparation containing the salts or crystalline forms.

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Patent Owner(s)

Patent OwnerAddress
TOPHARMAN SHANGHAI CO LTDBUILDING 1 LANE 388 GALILEO ROAD ZHANGJIANG HI TECH PARK PUDONG NEW AREA SHANGHAI 201203 SHANGHAI CITY SHANGHAI CITY 201203
TOPHARMAN SHANGDONG CO LTD40 WENSHUIBEILU ECONOMIC DEVELOPMENT ZONE ANQIU CITY SHANGDON 262123
SHANGHAI INSTITUE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES555 ZUCHONGZHI ROAD ZHANGJIANG PUDONG SHANGHAI 201203

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jiang, Hualiang Shanghai, CN 58 37
Jiang, Xiangrui Shanghai, CN 13 6
Li, Jianfeng Shanghai, CN 76 407
Liu, Zheng Shanghai, CN 491 1992
Shen, Jingshan Shanghai, CN 29 32
Suo, Jin Shanghai, CN 6 26
Tian, Guanghui Shanghai, CN 16 21
Wang, Zhen Shanghai, CN 578 1891
Xie, Zhu Shanghai, CN 1 0
Yang, Xiaojun Shanghai, CN 39 214
Zhao, Xianguo Shanghai, CN 7 0
Zhu, Weiliang Shanghai, CN 10 14

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