4-benzyl-1-phenethyl-piperazine-2,6-dione preparation method, and intermediate and preparation method thereof

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United States of America Patent

PATENT NO 9527804
APP PUB NO 20160130218A1
SERIAL NO

14899350

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Abstract

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The present invention provides a key new intermediate (a compound of formula III) of 4-benzyl-1-phenethyl-piperazine-2,6-dione (formula IV compound), a pharmaceutically acceptable salt thereof and a preparation method thereof. The present invention additionally discloses a method for preparing 4-benzyl-1-phenethyl-piperazine-2,6-dione (formula IV compound) from the formula III compound, said method overcoming the shortcomings of current formula IV compound preparation methods, such as low production volumes, low purity, high energy consumption, high costs, and inability to achieve industrialized production, and provides a formula IV compound preparation method which is simple, economical, environmentally-friendly and easy to produce industrially; the reaction solvent of the method is easily recycled and the method can produce the formula IV compound at high production rates and with high purity.

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Patent Owner(s)

Patent OwnerAddress
ZHEJIANG HISUN PHARMACEUTICAL CO LTDJIAOJIANG DISTRICT OF TAIZHOU CITY ZHEJIANG PROVINCE 318000 ROAD OUTSIDE NO 46 TAIZHOU CITY ZHEJIANG PROVINCE 318000
SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY200040 NO 1320 WEST BEIJING ROAD SHANGHAI SHANGHAI CITY SHANGHAI CITY 200040

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bao, Rusheng Taizhou, CN 4 2
Jiang, Dongming Taizhou, CN 39 519
Jin, Linyong Shanghai, CN 1 0
Pan, Hu Shanghai, CN 3 3
Pan, Linyu Shanghai, CN 1 0
Qiu, Pengcheng Shanghai, CN 4 1
Xu, Weiwei Taizhou, CN 70 261
Yang, Zhezhou Shanghai, CN 4 1
Zhang, Fuli Shanghai, CN 12 4

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