Inhibitors of beta-secretase

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United States of America Patent

PATENT NO 9526727
APP PUB NO 20150150872A1
SERIAL NO

14613550

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Abstract

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The present invention relates to spirocyclic acylguanidines and their use as inhibitors of theβ-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.

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Patent Owner(s)

Patent OwnerAddress
VITAE PHARMACEUTICALS INC502 WEST OFFICE CENTER DRIVE FORT WASHINGTON PA 19034

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bukhtiyarov, Yuri Boothwyn, US 9 37
Cacatian, Salvacion Conshohocken, US 49 482
Dillard, Lawrence Wayne Yardley, US 31 225
Dorner-Ciossek, Cornelia Ingelheim am Rhein, DE 41 281
Fuchs, Klaus Ingelheim am Rhein, DE 42 389
Jia, Lanqi Horsham, US 42 281
Lala, Deepak S Lower Gwynedd, US 8 55
Morales-Ramos, Angel Blue Bell, US 15 101
Rast, Georg Ingelheim am Rhein, DE 8 76
Reeves, Jonathan Ridgefield, US 71 1398
Singh, Suresh B Kendall Park, US 95 1396
Venkatraman, Shankar Lansdale, US 106 957
Xu, Zhenrong Chalfont, US 57 628
Yuan, Jing Lansdale, US 135 622
Zhao, Yi Blue Bell, US 234 2740
Zheng, Yajun Hockessin, DE 73 365

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