Phl p 5a derivatives having reduced allergeneity and retained T-cell reactivity
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United States of America Patent
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Dec 20, 2016
Grant Date -
Sep 11, 2014
app pub date -
Jan 2, 2014
filing date -
Jun 4, 2003
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Abstract
The present invention relates to the preparation and use of variants of the group 5 allergen of the Pooideae which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially retained reactivity with T lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventative immunotherapy of grass pollen allergies.
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