Polymeric nanoparticle solution composition and its manufacturing process
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United States of America Patent
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Dec 20, 2016
Grant Date -
Nov 13, 2014
app pub date -
Dec 7, 2012
filing date -
Dec 16, 2011
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Abstract
Disclosed are a polymeric drug carrier-containing pharmaceutical composition with enhanced stability in its solution state and a method for stabilizing the same. More particularly, disclosed are a pharmaceutical aqueous solution composition for storage under refrigeration containing a polymeric drug carrier comprising an amphiphilic block copolymer comprised of a hydrophilic block and a hydrophobic block, and a polylactic acid derivative fixed with a di- or tri-valent metal ion at its terminal carboxyl group and having preservation stability for at least 6 months, preferably at least 12 months when stored under refrigeration, and a method for stabilizing the same.
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