Aryl substituted carboxamide derivatives as calcium or sodium channel blockers
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United States of America Patent
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Dec 20, 2016
Grant Date -
Nov 12, 2015
app pub date -
Jul 2, 2015
filing date -
May 29, 2009
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Abstract
The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S) blocker such as NaV1.3 and NaV1.7, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved.
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