Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same
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United States of America Patent
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Dec 13, 2016
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Aug 26, 2014
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May 22, 2002
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Abstract
Compositions are provided, which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability.
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