Temperature dependent activation of catalytic nucleic acids for controlled active substance release
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United States of America Patent
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Dec 13, 2016
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Apr 25, 2013
app pub date -
Dec 16, 2010
filing date -
Dec 16, 2009
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Abstract
The present invention relates to an active substance release system containing two compounds. The first compound comprises a nanoparticle, combined with an oligonucleotide inhibition strand that is hybridized with a catalytically active nucleic acid. The second compound comprises a carrier, combined with a substrate molecule that is coupled to a therapeutic active substance. By means of external stimulation, the catalytically active nucleic acid of the first compound is released and specifically binds to the substrate molecule of the second compound. This leads to cleavage of the substrate molecule, whereby the active substance bound thereto is released.
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