Digital holographic method of measuring cellular activity and measuring apparatus with improved stability

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United States of America Patent

PATENT NO 9514271
SERIAL NO

13704438

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Abstract

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Motility contrast imaging (MCI) is a depth-resolved holographic technique to extract cellular and subcellular motion inside tissue. The holographic basis of the measurement technique makes it highly susceptible to mechanical motion. The motility contrast application, in particular, preferably includes increased mechanical stability because the signal is based on time-varying changes caused by cellular motion, which should not be confused with mechanical motion of the system. Apparatus for motility contrast imaging that provides increased mechanical stability is disclosed. It is based on common-path configurations, in which the signal and reference beams share optical elements in their paths to the detector. The two beams share mechanical motions in common, and hence these motions do not contribute to the signal.

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Patent Owner(s)

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PURDUE RESEARCH FOUNDATION101 FOUNDRY DRIVE SUITE 2500 WEST LAFAYETTE IN 47906

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nolte, David D Lafayette, US 29 642

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