Global proteomic screening of random bead arrays using mass spectrometry imaging
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United States of America Patent
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Dec 6, 2016
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app pub date -
Dec 17, 2013
filing date -
Jun 30, 2010
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Abstract
Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
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