Combination therapy for the treatment of cancer and immunosuppression
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United States of America Patent
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Dec 6, 2016
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Jun 11, 2015
app pub date -
Jul 3, 2013
filing date -
Jul 10, 2012
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Abstract
The invention relates to novel Rauwolfia alkaloid derivatives of formula (I) combinations of Rauwolfia alkaloid derivatives and a mitochondrial inhibitor, e.g. metformin, and the use of Rauwolfia alkaloid derivatives in combination with mitochondrial inhibitor for the treatment of cancer and for achieving clinical immunosuppression. The invention also relates to a fluorescence-based method for predicting the sensitivity of a cancer cell towards a compound of formula (I).
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